1-Boc-3-azetidineacetic acid ethyl ester

1-Boc-3-azetidineacetic acid ethyl ester - Names and Identifiers

Name	1-Boc-3-azetidineacetic acid ethyl ester
Synonyms	Ethyl 1-Boc-3-azetidineacetate tert-Butyl 3-(2-ethoxy-2-oxoethyl) 1-Boc-3-(2-ethoxy-2-oxoethyl)azetidine 1-Boc-3-azetidineacetic acid ethyl ester Ethyl 1-(tert-Butoxycarbonyl)-3-azetidineacetate 1-(tert-Butoxycarbonyl)-3-(2-ethoxy-2-oxoethyl)azetidine 3-Ethoxycarbonylmethyl-azetidine-1-carboxylic acid tert-butyl ester 3-Azetidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester
CAS	158602-35-8

1-Boc-3-azetidineacetic acid ethyl ester - Physico-chemical Properties

Molecular Formula	C12H21NO4
Molar Mass	243.3
Density	1.089±0.06 g/cm3(Predicted)
Boling Point	303.0±15.0 °C(Predicted)
Appearance	clear liquid
Color	Colorless to Light yellow
pKa	-1.89±0.40(Predicted)
Storage Condition	2-8°C

1-Boc-3-azetidineacetic acid ethyl ester - Introduction

1-Boc-3-azetidineacetic acid ethyl ester is an organic compound whose structural formula is Boc-NH(CH2)3OOCCH3. The following is a description of its nature, use, formulation and safety information:

Nature:
1-boc-3-azetidineaceacetic acid ethyl ester is a solid, common white crystal. It has low solubility at room temperature and is better soluble in some organic solvents, such as dimethylformamide (DMF) or dichloromethane.

Use:
1-boc-3-azetidineaceacetic acid ester is an intermediate widely used in organic synthesis. It can be used to prepare various azetidine derivatives, which have important biological activities. In addition, 1-boc-3-azetidineaceacetic acid ester is also commonly used as a proton acceptor and amino protecting agent.

Method:
1-Boc-3-azetidineacetic acid ethyl ester can be obtained by reacting 1-azetidinamine with ethyl 2-bromoacetate, followed by reaction with Boc2O. The reaction process needs to be carried out under an inert atmosphere, and the reaction is usually carried out under the protection of nitrogen.

Safety Information:
1-boc-3-azetidineaceacetic acid ethyl ester has low toxicity under normal operating conditions. However, it is still a chemical, so it is necessary to pay attention to the relevant safety measures. When using, to maintain good ventilation conditions, avoid contact with skin and eyes. If inhaled or exposed, seek medical help immediately. In addition, the compound is stored in a dry, cool place and left with flammable and oxidant Wells.

Last Update：2024-04-09 20:52:54